Talk Python To Me
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Talk Python To Me
Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly lear...
Recent Episodes
559 episodes
#560: Building a Research OS: From Django to 30,000 Samples
In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years from three ci...
#559: 12 Things You Should (and Shouldn't) Do in AWS
Your site is down. It's 3am. Is it a bug, a bill, or a breach? You can't tell yet, and everyone is watching you find out. Matt Lea has spent fifteen y...
#558: Hyper-Personal Software with Python
Every company has one. The little internal tool that Jane built back in 2021, and then Jane left. Nobody understands it, nobody will touch it. There a...
#557: Security of everything at PyCon 2026
Security has always been the vegetables of software. Everyone agrees it matters, and somehow it never quite makes it onto the plate. At PyCon US this...
#556: Updates on Django's Async Story
For years, "Django and async" came with an asterisk. The docs themselves warned you off it. Scary performance notes, a story that felt half-finished....
#555: Marimo Pair - A Canvas for Agent + Developers Collaboration
Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But t...
#554: Trustworthy AI in Healthcare and Longevity
You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the ques...
#553: All of our tools
This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on...
#552: Astral joins OpenAI
OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's th...
#551: Stroll Down Startup Lane - 2026
If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on...
#550: AI Contributions and Maintainer Load in Open Source
You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue...
#549: Great Docs
Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Mich...
#548: Event Sourcing Design Pattern
What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly...
#547: Parallel Python at Any Scale with Ray
When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkele...
#546: Self hosting apps for Python people
The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you r...
#545: OWASP Top 10 (2025 List) for Python Devs
The OWASP Top 10 just got a fresh update, and there are some big changes: supply chain attacks, exceptional condition handling, and more. Tanya Janca...
#544: Wheel Next + Packaging PEPs
When you pip install a package with compiled code, the wheel you get is built for CPU features from 2009. Want newer optimizations like AVX2? Your ins...
#543: Deep Agents: LangChain's SDK for Agents That Plan and Delegate
When you type a question into ChatGPT, the model only has what you typed to work with. But tools like Claude Code can plan, iterate, test, and recover...
#542: Zensical - a modern static site generator
If you've built documentation in the Python ecosystem, chances are you've used Martin Donath's work. His Material for MKDocs powers docs for FastAPI,...
#541: Monty - Python in Rust for AI
When LLMs write code to accomplish a task, that code has to actually run somewhere. And right now, the options aren't great. Spin up a sandboxed conta...
#540: Modern Python monorepo with uv and prek
Monorepos -- you've heard the talks, you've read the blog posts, maybe you've seen a few tantalizing glimpses into how Google or Meta organize their m...
#539: Catching up with the Python Typing Council
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#538: Python in Digital Humanities
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#537: Datastar: Modern web dev, simplified
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#536: Fly inside FastAPI Cloud
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#535: PyView: Real-time Python Web Apps
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#534: diskcache: Your secret Python perf weapon
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#533: Web Frameworks in Prod by Their Creators
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#532: 2025 Python Year in Review
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#531: Talk Python in Production
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#530: anywidget: Jupyter Widgets made easy
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#529: Computer Science from Scratch
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#528: Python apps with LLM building blocks
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#527: MCP Servers for Python Devs
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#526: Building Data Science with Foundation LLM Models
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#525: NiceGUI Goes 3.0
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#524: 38 things Python developers should learn in 2025
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#523: Pyrefly: Fast, IDE-friendly typing for Python
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#522: Data Sci Tips and Tricks from CodeCut.ai
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#521: Red Teaming LLMs and GenAI with PyRIT
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